High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design
High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design
Crystal structures of an mRNA-capping enzyme from SARS-CoV-2 in complex with its substrates suggest targets for drug design.
- Northwestern University United States
- Northwestern University United States
- Northeastern University United States
- Northwestern University Medical School United States
Models, Molecular, Adenosine, Genes, Viral, Protein Conformation, Pneumonia, Viral, Crystallography, X-Ray, RNA Cap Analogs, Biochemistry, Methylation, Article, Betacoronavirus, Open Reading Frames, Catalytic Domain, Humans, RNA Processing, Post-Transcriptional, Molecular Biology, Pandemics, Binding Sites, COVID-19, Cell Biology, Methyltransferases, Coronavirus Infections, Dimerization, Protein Binding
Models, Molecular, Adenosine, Genes, Viral, Protein Conformation, Pneumonia, Viral, Crystallography, X-Ray, RNA Cap Analogs, Biochemistry, Methylation, Article, Betacoronavirus, Open Reading Frames, Catalytic Domain, Humans, RNA Processing, Post-Transcriptional, Molecular Biology, Pandemics, Binding Sites, COVID-19, Cell Biology, Methyltransferases, Coronavirus Infections, Dimerization, Protein Binding
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