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Science Signaling
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High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design

Authors: Rosas-Lemus, Monica; Minasov, George; Shuvalova, Ludmilla; Inniss, Nicole L.; Kiryukhina, Olga; Brunzelle, Joseph; Satchell, Karla J. F.;

High-resolution structures of the SARS-CoV-2 2′- O -methyltransferase reveal strategies for structure-based inhibitor design

Abstract

Crystal structures of an mRNA-capping enzyme from SARS-CoV-2 in complex with its substrates suggest targets for drug design.

Keywords

Models, Molecular, Adenosine, Genes, Viral, Protein Conformation, Pneumonia, Viral, Crystallography, X-Ray, RNA Cap Analogs, Biochemistry, Methylation, Article, Betacoronavirus, Open Reading Frames, Catalytic Domain, Humans, RNA Processing, Post-Transcriptional, Molecular Biology, Pandemics, Binding Sites, COVID-19, Cell Biology, Methyltransferases, Coronavirus Infections, Dimerization, Protein Binding

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    160
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 0.1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
160
Top 1%
Top 10%
Top 0.1%
Green
hybrid