Epithelial‐specific requirement of FGFR2 signaling during tooth and palate development
Copyright policy )Epithelial‐specific requirement of FGFR2 signaling during tooth and palate development
AbstractReciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role in epithelial–mesenchymal tissue interaction. We have generated epithelial‐specific conditional knockout mice targeting Fibroblast growth factor receptor 2 (Fgfr2) to investigate the function of FGF signaling during craniofacial development.K14‐Cre;Fgfr2fl/flmice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells ofK14‐Cre;Fgfr2fl/flmice is reduced. Thus, FGF signaling via FGFR2 in the epithelium is crucial for cell proliferation activity during tooth and palate development.J. Exp. Zool. (Mol. Dev. Evol.) 312B:343–350, 2009. © 2009 Wiley‐Liss, Inc.
- University of Southern California United States
- University of California System United States
- Meikai University Japan
Cleft Palate, Mice, Palate, Animals, Epithelial Cells, Receptor, Fibroblast Growth Factor, Type 2, Tooth, In Situ Hybridization, Signal Transduction
Cleft Palate, Mice, Palate, Animals, Epithelial Cells, Receptor, Fibroblast Growth Factor, Type 2, Tooth, In Situ Hybridization, Signal Transduction
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