Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain
Copyright policy )Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain
We report the first structure of a vaccine-induced antibody to SARS-CoV-2 spike isolated from plasmablasts 7 days after vaccination. The genetic sequence of the antibody PVI.V6-14 suggests that it is completely unmutated, meaning that this type of B cell did not undergo somatic hypermutation or affinity maturation; this cell was likely already present in the donor and was activated by the vaccine.
- University of Mary United States
- Washington University in St. Louis School of Medicine United States
- Washington University in St. Louis United States
- Icahn School of Medicine at Mount Sinai United States
570, COVID-19 Vaccines, coronavirus, Antibodies, Viral, Microbiology, Antibodies, Epitopes, vaccine, Monoclonal, Humans, Viral, Neutralizing, electron microscopy, SARS-CoV-2, Biliverdine, Antibodies, Monoclonal, COVID-19, adaptive immunity, Antibodies, Neutralizing, Spike Glycoprotein, QR1-502, Coronavirus, Germ Cells, Spike Glycoprotein, Coronavirus, monoclonal antibodies, Research Article
570, COVID-19 Vaccines, coronavirus, Antibodies, Viral, Microbiology, Antibodies, Epitopes, vaccine, Monoclonal, Humans, Viral, Neutralizing, electron microscopy, SARS-CoV-2, Biliverdine, Antibodies, Monoclonal, COVID-19, adaptive immunity, Antibodies, Neutralizing, Spike Glycoprotein, QR1-502, Coronavirus, Germ Cells, Spike Glycoprotein, Coronavirus, monoclonal antibodies, Research Article
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