Calcineurin Regulates Enteric Muscle Contraction Through EXP-1, Excitatory GABA-gated Channel, in C.elegans
Copyright policy )Calcineurin Regulates Enteric Muscle Contraction Through EXP-1, Excitatory GABA-gated Channel, in C.elegans
The enteric muscle contraction (EMC) is the last step of the defecation behavior which occurs every 50 s in Caenorhabditis elegans. This EMC is regulated by intestinal and anal depressor muscles, which are innervated by GABA motor neurons. Our data show that calcineurin (tax-6) is expressed in intestinal muscle and anal depressor muscle, and the gain-of-function mutant of calcineurin, tax-6(jh107), shows defects in enteric muscle contractions. In addition, the intracellular region of EXP-1, an excitatory GABA receptor, specifically binds to calcineurin A. This interaction between TAX-6 and EXP-1 appears to be independent of both calcium and CNB, which is the calcium-binding regulatory subunit. Genetic evidence of epistasis between cnb-1(jh103) and exp-1(sa6) suggests that calcineurin functions as a negative regulator of excitatory GABA receptor in GABA signaling in C.elegans.
- Gwangju Institute of Science and Technology Korea (Republic of)
Motor Neurons, Calcineurin, Molecular Sequence Data, Muscle, Smooth, Receptors, GABA, Digestive System Physiological Phenomena, Mutation, Animals, Amino Acid Sequence, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Digestive System, Muscle Contraction, Signal Transduction
Motor Neurons, Calcineurin, Molecular Sequence Data, Muscle, Smooth, Receptors, GABA, Digestive System Physiological Phenomena, Mutation, Animals, Amino Acid Sequence, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Digestive System, Muscle Contraction, Signal Transduction
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