Effects of Some Prostaglandins and Leukotrienes on Lymphocytes, Monocytes and Their Activity in vitro
Copyright policy )Effects of Some Prostaglandins and Leukotrienes on Lymphocytes, Monocytes and Their Activity in vitro
The effect of some prostaglandins (PGs) and leukotrienes (LTs) on lymphocytes and monocytes was tested in vitro. Overnight incubation with PGD<sub>2</sub> reduces the expression of Leu-2 antigen (suppressor/cytotoxic phenotype) and of Fc receptors for IgG. PGA<sub>2</sub>, PGD<sub>2</sub> and to a lesser extent PGE<sub>2</sub> inhibit PHA reactivity of lymphocytes. LTB<sub>4</sub> does not have any inhibitory activity. Preincubation of lymphocytes with PGD<sub>2</sub> and PGE<sub>2</sub> decreases their NK activity. LTB<sub>4</sub>, but not the PGs tested, stimulates monocyte metabolism as assessed by chemiluminescence.
- Karolinska Institute Sweden
- Stockholm County Council Sweden
Antigens, Differentiation, T-Lymphocyte, Prostaglandin D2, Prostaglandins D, Prostaglandins E, Receptors, Fc, Lymphocyte Activation, Leukotriene B4, Dinoprostone, Monocytes, Killer Cells, Natural, Phenotype, Antigens, Surface, Luminescent Measurements, Prostaglandins, Humans, Drug Interactions, Lymphocytes, Phytohemagglutinins, Cells, Cultured
Antigens, Differentiation, T-Lymphocyte, Prostaglandin D2, Prostaglandins D, Prostaglandins E, Receptors, Fc, Lymphocyte Activation, Leukotriene B4, Dinoprostone, Monocytes, Killer Cells, Natural, Phenotype, Antigens, Surface, Luminescent Measurements, Prostaglandins, Humans, Drug Interactions, Lymphocytes, Phytohemagglutinins, Cells, Cultured
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