Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex
Copyright policy )Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex
Transcription activation by RNA polymerase II is a complicated process driven by combined, precisely coordinated action of a wide array of coactivator complexes, which carry out chromatin-directed activities and nucleate the assembly of the preinitiation complex on the promoter. Using various techniques, we have shown the existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, named BTFly (Brahma and TFIID in one assembly). The coupling of Brahma and TFIID is mediated by the SAYP factor, whose evolutionarily conserved activation domain SAY can directly bind to both BAP170 subunit of Brahma and TAF5 subunit of TFIID. The integrity of BTFly is crucial for its ability to activate transcription. BTFly is distributed genome-wide and appears to be a means of effective transcription activation.
- University of Oslo Norway
- Department of Biological Sciences Russian Federation
- Russian Academy of Sciences Russian Federation
- Institute of Gene Biology Russian Federation
Transcriptional Activation, Embryo, Nonmammalian, Cell Cycle Proteins, Chromatin Assembly and Disassembly, Cell Line, Protein Structure, Tertiary, Molecular Weight, Drosophila melanogaster, Multiprotein Complexes, Trans-Activators, Animals, Drosophila Proteins, Transcription Factor TFIID, Protein Binding, Transcription Factors
Transcriptional Activation, Embryo, Nonmammalian, Cell Cycle Proteins, Chromatin Assembly and Disassembly, Cell Line, Protein Structure, Tertiary, Molecular Weight, Drosophila melanogaster, Multiprotein Complexes, Trans-Activators, Animals, Drosophila Proteins, Transcription Factor TFIID, Protein Binding, Transcription Factors
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