RVB1/RVB2: Running Rings around Molecular Biology
Copyright policy )RVB1/RVB2: Running Rings around Molecular Biology
RVB1/RVB2 (also known as Pontin/Reptin, TIP49/TIP48, RuvbL1/RuvbL2, ECP54/ECP51, INO80H/INO80J, TIH1/TIH2, and TIP49A/TIP49B) are two highly conserved members of the AAA+ family that are present in different protein and nucleoprotein complexes. Recent studies implicate the RVB-containing complexes in many cellular processes such as transcription, DNA damage response, snoRNP assembly, cellular transformation, and cancer metastasis. In this review, we discuss recent advances in our understanding of RVB-containing complexes and their role in these pathways.
- University of Virginia United States
DNA Replication, Models, Molecular, Transcriptional Activation, Saccharomyces cerevisiae Proteins, DNA Repair, Molecular Sequence Data, DNA Helicases, Mitosis, Cell Biology, Chromatin Assembly and Disassembly, Cell Transformation, Neoplastic, Ribonucleoproteins, Small Nucleolar, ATPases Associated with Diverse Cellular Activities, Humans, Amino Acid Sequence, Carrier Proteins, Molecular Biology, DNA Damage
DNA Replication, Models, Molecular, Transcriptional Activation, Saccharomyces cerevisiae Proteins, DNA Repair, Molecular Sequence Data, DNA Helicases, Mitosis, Cell Biology, Chromatin Assembly and Disassembly, Cell Transformation, Neoplastic, Ribonucleoproteins, Small Nucleolar, ATPases Associated with Diverse Cellular Activities, Humans, Amino Acid Sequence, Carrier Proteins, Molecular Biology, DNA Damage
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