Overexpression of malic enzyme in the larval stage extends Drosophila lifespan
Copyright policy )Overexpression of malic enzyme in the larval stage extends Drosophila lifespan
Metabolic modifications during the developmental period can extend longevity. We found that malic enzyme (Men) overexpression during the larval period lengthened the lifespan of Drosophila. Men overexpression by S106-GeneSwitch-Gal4 driver increased pyruvate content and NADPH/NADP(+) ratio but reduced triglyceride, glycogen, and ATP levels in the larvae. ROS levels increased unexpectedly in Men-overexpressing larvae. Interestingly, adults exposed to larval Men-overexpression maintained ROS tolerance with enhanced expression levels of glutathione-S-transferase D2 and thioredoxin-2. Our results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila.
- Korea University Korea (Republic of)
Longevity, Adenosine Triphosphate, Drosophila melanogaster, Thioredoxins, Malate Dehydrogenase, Larva, Pyruvic Acid, Animals, Drosophila Proteins, Reactive Oxygen Species, Glycogen, NADP, Triglycerides, Glutathione Transferase
Longevity, Adenosine Triphosphate, Drosophila melanogaster, Thioredoxins, Malate Dehydrogenase, Larva, Pyruvic Acid, Animals, Drosophila Proteins, Reactive Oxygen Species, Glycogen, NADP, Triglycerides, Glutathione Transferase
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