Tbr1 Regulates Differentiation of the Preplate and Layer 6
Copyright policy )Tbr1 Regulates Differentiation of the Preplate and Layer 6
During corticogenesis, early-born neurons of the preplate and layer 6 are important for guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1-deficient mice, these early-born neurons had molecular and functional defects. Cajal-Retzius cells expressed decreased levels of Reelin, resulting in a reeler-like cortical migration disorder. Impaired subplate differentiation was associated with ectopic projection of thalamocortical fibers into the basal telencephalon. Layer 6 defects contributed to errors in the thalamocortical, corticothalamic, and callosal projections. These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development.
- University of California, Los Angeles United States
- Harvard University United States
- Howard Hughes Medical Institute United States
- University of California, San Francisco United States
Neurons, Extracellular Matrix Proteins, Cell Death, Neuroscience(all), Cell Adhesion Molecules, Neuronal, Serine Endopeptidases, Gene Expression Regulation, Developmental, Mice, Transgenic, Neocortex, Nerve Tissue Proteins, Synaptic Transmission, Mice, Mutant Strains, DNA-Binding Proteins, Mice, Reelin Protein, Lac Operon, Cell Movement, Mutation, Neural Pathways, Animals, Germ Layers
Neurons, Extracellular Matrix Proteins, Cell Death, Neuroscience(all), Cell Adhesion Molecules, Neuronal, Serine Endopeptidases, Gene Expression Regulation, Developmental, Mice, Transgenic, Neocortex, Nerve Tissue Proteins, Synaptic Transmission, Mice, Mutant Strains, DNA-Binding Proteins, Mice, Reelin Protein, Lac Operon, Cell Movement, Mutation, Neural Pathways, Animals, Germ Layers
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).771 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!