Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy
Copyright policy )Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy
Cognitive function is impaired in patients with hepatic encephalopathy. Learning ability is also impaired in rats with hepatic encephalopathy due to portacaval shunts. Long-term potentiation (LTP) in hippocampus, considered the basis of some forms of learning and memory, is impaired in rats with portacaval shunt. We analyzed the mechanisms by which LTP is impaired in these rats. In control rats, application of the tetanus to induce LTP increases phosphorylation of Thr286 of calcium-calmodulin dependent protein kinase II. This activates the kinase which phosphorylates the GluR1 subunit of AMPA receptors in Ser831 and induces its translocation to the post-synaptic densities. All these steps are completely prevented in rats with hepatic encephalopathy in which the tetanus does not induce phosphorylation of CaMKII or GluR1 nor translocation of this subunit to the post-synaptic membrane. This would explain the impairment in LTP in these rats.
Male, Trafficking, Blotting, Western, Long-Term Potentiation, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Hippocampus, Electric Stimulation, Rats, Hepatic Encephalopathy, Long-term potentiation, Animals, Receptors, AMPA, Phosphorylation, Rats, Wistar, AMPA receptors, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Disks Large Homolog 4 Protein, Hepatic encephalopathy, Synaptosomes
Male, Trafficking, Blotting, Western, Long-Term Potentiation, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Hippocampus, Electric Stimulation, Rats, Hepatic Encephalopathy, Long-term potentiation, Animals, Receptors, AMPA, Phosphorylation, Rats, Wistar, AMPA receptors, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Disks Large Homolog 4 Protein, Hepatic encephalopathy, Synaptosomes
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).5 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!