A Circadian Sleep Disorder Reveals a Complex Clock
Copyright policy )A Circadian Sleep Disorder Reveals a Complex Clock
Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1delta and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.
- Stanford University United States
- Northeastern University United States
- Howard Hughes Medical Institute United States
- Northwestern University United States
- Northwestern University United States
Mice, Biochemistry, Genetics and Molecular Biology(all), Biological Clocks, Casein Kinase I, Sleep Disorders, Circadian Rhythm, Mutation, Animals, Humans, Nuclear Proteins, Period Circadian Proteins, Phosphorylation, Models, Biological, Transcription Factors
Mice, Biochemistry, Genetics and Molecular Biology(all), Biological Clocks, Casein Kinase I, Sleep Disorders, Circadian Rhythm, Mutation, Animals, Humans, Nuclear Proteins, Period Circadian Proteins, Phosphorylation, Models, Biological, Transcription Factors
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