Evolutionary clustering and functional similarity of RNA‐binding proteins
Copyright policy )Evolutionary clustering and functional similarity of RNA‐binding proteins
RNA‐binding proteins (RNPs) involved in splicing, processing and translation regulation contain one to four RNA‐binding domains. We constructed a phylogenetic tree for the RNA‐binding domains, including those of poly(A)‐binding protein (PABP), splicing factors, chloroplast RNPs, hnRNPs, snRNP U1‐70K, nucleolin and Drosophila sex determinants. Proteins with similar functions were found to have closely related RNA‐binding domains and common domain organizations. In light of these observation, one can assume the function of an RNA‐binding protein, based on the evolutionary relationship between its RNA‐binding domain(s) and domain organization, as compared with other RNPs.
- Nagoya University Japan
Splicing factor, Chloroplasts, Poly(A)-binding protein, Gene duplication., RNA-Binding Proteins, Ribonucleoprotein, RNA-binding domain, Biological Evolution, Drosophila sex determinant, Animals, Humans, Conserved Sequence, Phylogeny
Splicing factor, Chloroplasts, Poly(A)-binding protein, Gene duplication., RNA-Binding Proteins, Ribonucleoprotein, RNA-binding domain, Biological Evolution, Drosophila sex determinant, Animals, Humans, Conserved Sequence, Phylogeny
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