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The Complete Genome Sequence of Escherichia coli K-12

Authors: F R, Blattner; G, Plunkett; C A, Bloch; N T, Perna; V, Burland; M, Riley; J, Collado-Vides; +10 Authors

The Complete Genome Sequence of Escherichia coli K-12

Abstract

The 4,639,221–base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbes reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident. The largest family of paralogous proteins contains 80 ABC transporters. The genome as a whole is strikingly organized with respect to the local direction of replication; guanines, oligonucleotides possibly related to replication and recombination, and most genes are so oriented. The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer.

Keywords

DNA Replication, DNA, Bacterial, Recombination, Genetic, Base Composition, Binding Sites, Molecular Sequence Data, Chromosome Mapping, Sequence Analysis, DNA, Regulatory Sequences, Nucleic Acid, Bacteriophage lambda, RNA, Bacterial, Bacterial Proteins, RNA, Transfer, Genes, Bacterial, Mutation, Operon, DNA Transposable Elements, Escherichia coli, Genome, Bacterial, Repetitive Sequences, Nucleic Acid

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7K
Top 0.01%
Top 0.01%
Top 0.01%