The Complete Genome Sequence of Escherichia coli K-12
pmid: 9278503
The Complete Genome Sequence of Escherichia coli K-12
The 4,639,221–base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbes reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident. The largest family of paralogous proteins contains 80 ABC transporters. The genome as a whole is strikingly organized with respect to the local direction of replication; guanines, oligonucleotides possibly related to replication and recombination, and most genes are so oriented. The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer.
- University of Wisconsin–Madison United States
- University of Wisconsin–Oshkosh United States
- University of Wisconsin System United States
- Eastern Michigan University United States
DNA Replication, DNA, Bacterial, Recombination, Genetic, Base Composition, Binding Sites, Molecular Sequence Data, Chromosome Mapping, Sequence Analysis, DNA, Regulatory Sequences, Nucleic Acid, Bacteriophage lambda, RNA, Bacterial, Bacterial Proteins, RNA, Transfer, Genes, Bacterial, Mutation, Operon, DNA Transposable Elements, Escherichia coli, Genome, Bacterial, Repetitive Sequences, Nucleic Acid
DNA Replication, DNA, Bacterial, Recombination, Genetic, Base Composition, Binding Sites, Molecular Sequence Data, Chromosome Mapping, Sequence Analysis, DNA, Regulatory Sequences, Nucleic Acid, Bacteriophage lambda, RNA, Bacterial, Bacterial Proteins, RNA, Transfer, Genes, Bacterial, Mutation, Operon, DNA Transposable Elements, Escherichia coli, Genome, Bacterial, Repetitive Sequences, Nucleic Acid
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