Glial cell line-derived neurotrophic factor (GDNF) family ligands reduce the sensitivity of neuroblastoma cells to pharmacologically induced cell death, growth arrest and differentiation
Copyright policy )Glial cell line-derived neurotrophic factor (GDNF) family ligands reduce the sensitivity of neuroblastoma cells to pharmacologically induced cell death, growth arrest and differentiation
The glial cell line-derived neurotrophic factor (GDNF) family of ligands play essential roles in promoting normal neural crest differentiation during embryogenesis, and, may have a therapeutic role in malignancies of neural crest origin, such as neuroblastoma. However, we report here that GDNF and neurturin blocked the growth inhibitory and neuritogenic effects of all-trans-retinoic acid in neuroblastoma cells in vitro. GDNF caused neuroblastoma cells to proliferate in the presence of a range of cytotoxic chemotherapeutic agents at low concentrations. Thus, our findings suggest a role for GDNF signaling in promoting resistance to differentiation or cytotoxic therapy of neuroblastoma, and, preclude their use in this neural crest tumor.
- Boston Children's Hospital United States
- Sydney Children’s Hospitals Network Australia
- Sydney Children's Hospital Australia
Cytotoxins, Cell Cycle, Neurturin, Antineoplastic Agents, Cell Differentiation, Mice, Transgenic, Tretinoin, Ligands, Growth Inhibitors, Glial Cell Line-Derived Neurotrophic Factors, Mice, Neuroblastoma, Drug Resistance, Neoplasm, Cell Line, Tumor, Animals, Humans, Glial Cell Line-Derived Neurotrophic Factor, Cell Proliferation, Signal Transduction
Cytotoxins, Cell Cycle, Neurturin, Antineoplastic Agents, Cell Differentiation, Mice, Transgenic, Tretinoin, Ligands, Growth Inhibitors, Glial Cell Line-Derived Neurotrophic Factors, Mice, Neuroblastoma, Drug Resistance, Neoplasm, Cell Line, Tumor, Animals, Humans, Glial Cell Line-Derived Neurotrophic Factor, Cell Proliferation, Signal Transduction
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