Association between suicide attempts and 5-HTTLPR-S-Allele in alcohol-dependent and control subjects: further evidence from a german alcohol-dependent inpatient sample
Copyright policy )Association between suicide attempts and 5-HTTLPR-S-Allele in alcohol-dependent and control subjects: further evidence from a german alcohol-dependent inpatient sample
Genetically-mediated alterations in serotonergic transmission have been implicated in both the pathogenesis of alcoholism and suicidal behavior. Thus, the identification of vulnerability genes could uncover pathophysiological links for both syndromes. A significant association between suicide attempts and the 5-HTT promoter polymorphisms (5-HTTLPR) S-allele has been reported in a sample of French alcohol-dependent subjects, and this paper evaluates this phenomenon in a German sample.One hundred and sixty-three patients meeting DSM-IV criteria for alcohol dependence and 117 healthy controls were investigated. Blood samples were taken to genotype the 5-HTTLPR by using polymerase chain reaction (PCR) of lymphocyte DNA.5-HTTLPR-S alleles were seen more frequently in suicidal compared to nonsuicidal alcohol-dependent subjects. Furthermore, significant effects from suicide attempts on the number of S-alleles were found.The results are consistent with an association between the 5-HTTLPR-S-allele and suicide attempts in alcohol-dependent subjects.
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Membrane Transport Proteins, Nerve Tissue Proteins, Suicide, Attempted, Middle Aged, Alcoholism, Risk Factors, Humans, Female, Genetic Predisposition to Disease, Carrier Proteins, Promoter Regions, Genetic, Alleles, Chromosomes, Human, Pair 17
Adult, Male, Serotonin Plasma Membrane Transport Proteins, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Membrane Transport Proteins, Nerve Tissue Proteins, Suicide, Attempted, Middle Aged, Alcoholism, Risk Factors, Humans, Female, Genetic Predisposition to Disease, Carrier Proteins, Promoter Regions, Genetic, Alleles, Chromosomes, Human, Pair 17
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