Gene–environment interaction analysis of serotonin system markers with adolescent depression
Copyright policy )Gene–environment interaction analysis of serotonin system markers with adolescent depression
We report analyses from a study of gene-environment interaction in adolescent depression. The sample was selected from 1990 adolescents aged 10-20 years: those with depression symptoms in the top or bottom 15% were identified and divided into high or low environmental risk groups. DNA was obtained from 377 adolescents, representing the four quadrants of high or low depression and high or low environmental risk. Markers within, or close to, each of the serotonergic genes 5HTT, HTR2A, HTR2C, MAOA (monoamine oxidase type A) and tryptophan hydroxylase (TPH) were genotyped. Environmental risk group was a nonsignificant predictor and sex was a significant predictor of the depression group. HTR2A and TPH significantly predicted the depression group, independent of the effects of sex, environmental risk group and their interaction. In addition, there was a trend for an effect of 5HTTLPR, which was significant in female subjects. Furthermore, there was a significant genotype-environmental risk interaction for 5HTTLPR in female subjects only, with the effect being in the same direction as another recent study, reaffirming that an important source of genetic heterogeneity is exposure to environmental risk.
- University of Hong Kong (香港大學) China (People's Republic of)
- Kings College London, University of London United Kingdom
- King's College London United Kingdom
Questionnaires, Risk, Adult, Male, Tryptophan Hydroxylase - Genetics, Adolescent, Genotype, Receptor, Serotonin, 5-Ht2c - Genetics, Psychology, Adolescent, 610, Nerve Tissue Proteins, Nerve Tissue Proteins - Genetics, Environment, Depression - Etiology - Genetics, Life Change Events, Genetic Heterogeneity, Sex Factors, Humans, Genetic Predisposition to Disease, Child, Promoter Regions, Genetic, Membrane Transport Proteins - Genetics, Monoamine Oxidase, Serotonin Plasma Membrane Transport Proteins, Family Health, Membrane Glycoproteins, Depression, Membrane Transport Proteins, Membrane Glycoproteins - Genetics, Genetic Predisposition To Disease, Serotonin - Metabolism, Receptor, Serotonin, 5-Ht2a - Genetics, Monoamine Oxidase - Genetics, Biological Markers, Female, Promoter Regions, Genetic - Genetics, Adolescent Psychology, Biomarkers
Questionnaires, Risk, Adult, Male, Tryptophan Hydroxylase - Genetics, Adolescent, Genotype, Receptor, Serotonin, 5-Ht2c - Genetics, Psychology, Adolescent, 610, Nerve Tissue Proteins, Nerve Tissue Proteins - Genetics, Environment, Depression - Etiology - Genetics, Life Change Events, Genetic Heterogeneity, Sex Factors, Humans, Genetic Predisposition to Disease, Child, Promoter Regions, Genetic, Membrane Transport Proteins - Genetics, Monoamine Oxidase, Serotonin Plasma Membrane Transport Proteins, Family Health, Membrane Glycoproteins, Depression, Membrane Transport Proteins, Membrane Glycoproteins - Genetics, Genetic Predisposition To Disease, Serotonin - Metabolism, Receptor, Serotonin, 5-Ht2a - Genetics, Monoamine Oxidase - Genetics, Biological Markers, Female, Promoter Regions, Genetic - Genetics, Adolescent Psychology, Biomarkers
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