Finding Functional Features in Saccharomyces Genomes by Phylogenetic Footprinting
Copyright policy )Finding Functional Features in Saccharomyces Genomes by Phylogenetic Footprinting
The sifting and winnowing of DNA sequence that occur during evolution cause nonfunctional sequences to diverge, leaving phylogenetic footprints of functional sequence elements in comparisons of genome sequences. We searched for such footprints among the genome sequences of six Saccharomyces species and identified potentially functional sequences. Comparison of these sequences allowed us to revise the catalog of yeast genes and identify sequence motifs that may be targets of transcriptional regulatory proteins. Some of these conserved sequence motifs reside upstream of genes with similar functional annotations or similar expression patterns or those bound by the same transcription factor and are thus good candidates for functional regulatory sequences.
- University of Mary United States
- Washington University in St. Louis United States
Binding Sites, Base Sequence, Gene Expression Profiling, Genes, Fungal, Molecular Sequence Data, Computational Biology, Saccharomyces cerevisiae, Sequence Analysis, DNA, Regulatory Sequences, Nucleic Acid, Saccharomyces, DNA, Intergenic, Genome, Fungal, Sequence Alignment, Algorithms, Conserved Sequence, Phylogeny, Transcription Factors
Binding Sites, Base Sequence, Gene Expression Profiling, Genes, Fungal, Molecular Sequence Data, Computational Biology, Saccharomyces cerevisiae, Sequence Analysis, DNA, Regulatory Sequences, Nucleic Acid, Saccharomyces, DNA, Intergenic, Genome, Fungal, Sequence Alignment, Algorithms, Conserved Sequence, Phylogeny, Transcription Factors
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