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Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation

Authors: Nandini Sharma; Navjeet Ahalawat; Padmani Sandhu; Erick Strauss; Jagannath Mondal; Ruchi Anand;

Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation

Abstract

Transfer of labile intermediate in bifunctional enzymes occurs via transient molecular tunnels controlled by allosteric signals.

Keywords

Binding Sites, Protein Conformation, Proteins, Molecular Dynamics Simulation, Catalysis, Molecular Docking Simulation, Allosteric Regulation, Ammonia, Mutation, Protein Interaction Domains and Motifs, Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor, Research Articles, Protein Binding

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    16
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
16
Top 10%
Average
Top 10%
Green
gold