IL-9 as a mediator of Th17-driven inflammatory disease
Copyright policy )IL-9 as a mediator of Th17-driven inflammatory disease
We report that like other T cells cultured in the presence of transforming growth factor (TGF) β, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-β as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. The data show that IL-9 neutralization and IL-9 receptor deficiency attenuates disease, and this correlates with decreases in Th17 cells and IL-6–producing macrophages in the central nervous system, as well as mast cell numbers in the regional lymph nodes. Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease.
- University of Alabama at Birmingham United States
- King's College London United Kingdom
- Alabama Agricultural and Mechanical University United States
- Kings College London, University of London United Kingdom
- University Hospital of Zurich Switzerland
Mice, Knockout, Receptors, Interleukin-9, 2403 Immunology, Encephalomyelitis, Autoimmune, Experimental, Brief Definitive Report, Interleukin-9, 610, 610 Medicine & health, 11359 Institute for Regenerative Medicine (IREM), T-Lymphocytes, Helper-Inducer, In Vitro Techniques, 10263 Institute of Experimental Immunology, Adoptive Transfer, Mice, Inbred C57BL, Mice, Spinal Cord, T-Lymphocyte Subsets, 2723 Immunology and Allergy, 570 Life sciences; biology, Animals, Female, Inflammation Mediators
Mice, Knockout, Receptors, Interleukin-9, 2403 Immunology, Encephalomyelitis, Autoimmune, Experimental, Brief Definitive Report, Interleukin-9, 610, 610 Medicine & health, 11359 Institute for Regenerative Medicine (IREM), T-Lymphocytes, Helper-Inducer, In Vitro Techniques, 10263 Institute of Experimental Immunology, Adoptive Transfer, Mice, Inbred C57BL, Mice, Spinal Cord, T-Lymphocyte Subsets, 2723 Immunology and Allergy, 570 Life sciences; biology, Animals, Female, Inflammation Mediators
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