Molecular diversity at the carboxyl terminus of human and rat tau
Copyright policy )Molecular diversity at the carboxyl terminus of human and rat tau
Although a long terminal isoform of tau was historically the first identified clone, no such isform has been thus far reported among species other than mouse. We show here that there are homologues of the long terminal isoform in human and rat, but in various forms in contrast to mouse. There are generated by a combination of multiple splice sites, which causes distinct molecular diversity at the carboxyl terminus of human and rat tau.
- University of Tokyo Japan
Brain Chemistry, Mice, Inbred ICR, DNA, Complementary, Base Sequence, RNA Splicing, Molecular Sequence Data, Exons, Polymerase Chain Reaction, Rats, Mice, Species Specificity, Alzheimer Disease, Sequence Homology, Nucleic Acid, Consensus Sequence, Animals, Humans, Female, Amino Acid Sequence, Down Syndrome, Sequence Alignment
Brain Chemistry, Mice, Inbred ICR, DNA, Complementary, Base Sequence, RNA Splicing, Molecular Sequence Data, Exons, Polymerase Chain Reaction, Rats, Mice, Species Specificity, Alzheimer Disease, Sequence Homology, Nucleic Acid, Consensus Sequence, Animals, Humans, Female, Amino Acid Sequence, Down Syndrome, Sequence Alignment
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