Clustering of C2H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes
Copyright policy )Clustering of C2H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes
Ninety-three phage clones identified by hybridization with a C2-H2 zinc finger sequence probe have been grouped into 23 genetic loci. Partial sequencing verified that each locus belonged to the zinc finger family. Oligonucleotide primer pairs were developed from these sequences to serve as STS markers for these loci. One or more clones from each locus was mapped onto human metaphase chromosomes by fluorescence in situ hybridization. Several loci map to identical chromosomal regions, indicating the possible presence of multigene clusters. Zinc finger loci were found to reside predominantly either in telomeric regions or in chromosomal bands known to exhibit chromosome fragility. Chromosome 19 carries a disproportionate fraction (10 of 23) of the mapped zinc finger loci.
- Yale University United States
Base Sequence, Chromosome Fragile Sites, Chromosome Fragility, Molecular Sequence Data, Chromosome Mapping, Fluorescent Antibody Technique, Nucleic Acid Hybridization, Zinc Fingers, DNA, Karyotyping, Humans, Amino Acid Sequence, Metaphase
Base Sequence, Chromosome Fragile Sites, Chromosome Fragility, Molecular Sequence Data, Chromosome Mapping, Fluorescent Antibody Technique, Nucleic Acid Hybridization, Zinc Fingers, DNA, Karyotyping, Humans, Amino Acid Sequence, Metaphase
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