The neural cell adhesion molecule is necessary for normal adult retinal ganglion cell number and survival
Copyright policy )The neural cell adhesion molecule is necessary for normal adult retinal ganglion cell number and survival
Retinal ganglion cells (RGCs) undergo apoptotic death in predictable time-dependant manners during development and as a consequence of injury. Recently, synthetic neural cell adhesion molecule (NCAM) agonists have been shown to provide neuroprotective support. Within the adult mouse retina, NCAM has been localized on all neurons and glia; however, no functional role has been determined. Using adult NCAM-/- mice, we directly tested the potential influence of NCAM on neuron survival in vivo and observed that, in NCAM-/- retinas, RGC densities are greater, RGC loss after injury is earlier and target tissue significantly influences adult RGC survival, all in contrast to wild-type retinas. Collectively, our results indicate that NCAM may play a vital role in regulating the developmental change in the effectiveness of local versus target-derived RGC trophic support and that, in the adult, endogenous NCAM influences the total number of CNS neurons and their survival following injury.
- Dalhousie University Canada
Mice, Knockout, Retinal Ganglion Cells, Time Factors, Cell Survival, Wheat Germ Agglutinins, Brain-Derived Neurotrophic Factor, Axotomy, Cell Count, Enzyme-Linked Immunosorbent Assay, Axons, Functional Laterality, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Microscopy, Electron, Transmission, Optic Nerve Injuries, Animals, Receptor, trkB, Neural Cell Adhesion Molecules, Cell Proliferation
Mice, Knockout, Retinal Ganglion Cells, Time Factors, Cell Survival, Wheat Germ Agglutinins, Brain-Derived Neurotrophic Factor, Axotomy, Cell Count, Enzyme-Linked Immunosorbent Assay, Axons, Functional Laterality, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Microscopy, Electron, Transmission, Optic Nerve Injuries, Animals, Receptor, trkB, Neural Cell Adhesion Molecules, Cell Proliferation
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).25 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!