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LFA-1 is critical for regulatory T cell homeostasis and function

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2009 English Publisher:Elsevier BVJournal:Molecular Immunology, volume 46, pages 2,424-2,428 (issn: 0161-5890,

Authors: Trent R. Schoeb; Scott R. Barnum; Daniel C. Bullard; Jillian E. Wohler;

doi: 10.1016/j.molimm.2009.04.004

pmid: 19428111

pmc: PMC4627944

LFA-1 is critical for regulatory T cell homeostasis and function

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Abstract

Cellular adhesion molecules involved in cell-to-cell mediated suppression by Tregs are not well characterized. We found that the majority of Tregs expressed LFA-1 but most strikingly that the frequency of Tregs in LFA-1(-/-) mice was significantly lower (approximately 50%) in the spleen, lymph nodes, and Peyer's patches compared to wild type controls. The reduction in LFA-1(-/-) Treg cells appears due in part to a reduced capacity of LFA-1(-/-) CD4(+)CD25(-) cells to be induced to become Tregs in the lymph nodes. Importantly, we found that LFA-1(-/-) Tregs fail to suppress T cell responses in vitro and have reduced function in vivo. Treg-mediated suppression does not depend on LFA-1 interactions with ICAM-1 on the surface of responder cells. Our data demonstrate that LFA-1 plays a critical role in regulatory T cell homeostasis and function.

Related Organizations

University of Alabama at Birmingham
United States

Keywords

Mice, Knockout, Interleukin-2 Receptor alpha Subunit, Cell Differentiation, Thymus Gland, In Vitro Techniques, Colitis, T-Lymphocytes, Regulatory, Lymphocyte Function-Associated Antigen-1, Mice, Peyer's Patches, CD4 Antigens, Animals, Homeostasis, Lymph Nodes, Spleen

49 Research products, page 1 of 5

Uncharacterized protein
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Intercellular adhesion molecule
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Integrin alpha-L
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Itgal protein
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Uncharacterized protein
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Integrin alpha L
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Uncharacterized protein
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Icam1 protein
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Uncharacterized protein
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MFLJ00114 protein
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	48
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%