Gut Microbiota Has a Widespread and Modifiable Effect on Host Gene Regulation
Copyright policy )Gut Microbiota Has a Widespread and Modifiable Effect on Host Gene Regulation
The composition of the gut microbiome has been associated with various aspects of human health, but the mechanism of this interaction is still unclear. We utilized a cellular system to characterize the effect of the microbiome on human gene expression. We showed that some of these changes in expression may be mediated by changes in chromatin accessibility. Furthermore, we validate the role of a specific microbe and show that changes in its abundance can modify the host gene expression response. These results show an important role of gut microbiota in regulating host gene expression and suggest that manipulation of microbiome composition could be useful in future therapies.
- Loyola University Chicago United States
- University of Minnesota United States
- University of Minesota United States
- Wayne State College United States
- University of Minnesota United States
gene expression, genomics, microbiome, Microbiology, QR1-502, Research Article
gene expression, genomics, microbiome, Microbiology, QR1-502, Research Article
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