Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Copyright policy )Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments. A promising drug target is the viral main protease M pro , which plays a key role in viral replication and transcription. Dai et al. designed two inhibitors, 11a and 11b, based on analyzing the structure of the M pro active site. Both strongly inhibited the activity of M pro and showed good antiviral activity in cell culture. Compound 11a had better pharmacokinetic properties and low toxicity when tested in mice and dogs, suggesting that this compound is a promising drug candidate. Science , this issue p. 1331
- Wuhan University China (People's Republic of)
- Nanjing University of Chinese Medicine China (People's Republic of)
- University of Shanghai for Science and Technology China (People's Republic of)
- Sichuan University China (People's Republic of)
- University of Chinese Academy of Sciences China (People's Republic of)
Male, Pneumonia, Viral, Drug Evaluation, Preclinical, Antiviral Agents, Betacoronavirus, Mice, Dogs, Catalytic Domain, Chlorocebus aethiops, Animals, Humans, Pandemics, Research Articles, Coronavirus 3C Proteases, Multidisciplinary, Molecular Structure, COVID-19, Protein Structure, Tertiary, Cysteine Endopeptidases, Drug Design, Female, Coronavirus Infections
Male, Pneumonia, Viral, Drug Evaluation, Preclinical, Antiviral Agents, Betacoronavirus, Mice, Dogs, Catalytic Domain, Chlorocebus aethiops, Animals, Humans, Pandemics, Research Articles, Coronavirus 3C Proteases, Multidisciplinary, Molecular Structure, COVID-19, Protein Structure, Tertiary, Cysteine Endopeptidases, Drug Design, Female, Coronavirus Infections
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