The variable number of tandem repeat polymorphism of platelet glycoprotein Ibα and risk of coronary heart disease
Copyright policy )The variable number of tandem repeat polymorphism of platelet glycoprotein Ibα and risk of coronary heart disease
AbstractGlycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ibα, the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ibα and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ibα is different among whites and African Americans. The B allele (with 3 repeats) of GP Ibα is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes. (Blood. 2004;103:963-965)
- Baylor College of Medicine United States
- The University of Texas Health Science Center at Houston United States
- The University of Texas System United States
Male, Genotype, Black People, Coronary Disease, Minisatellite Repeats, Middle Aged, White People, Cohort Studies, Black or African American, Platelet Glycoprotein GPIb-IX Complex, Risk Factors, Humans, Female, Alleles
Male, Genotype, Black People, Coronary Disease, Minisatellite Repeats, Middle Aged, White People, Cohort Studies, Black or African American, Platelet Glycoprotein GPIb-IX Complex, Risk Factors, Humans, Female, Alleles
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