Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells
Copyright policy )Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells
AbstractIncreasing evidence has shown that death signaling in T cells is regulated in a complicated way. Molecules other than death receptors can also trigger T-cell death. Here, we demonstrate for the first time that P-selectin glycoprotein ligand-1 (PSGL-1) or CD162 molecules cross-linked by an anti–PSGL-1 monoclonal antibody, TAB4, can trigger a death signal in activated T cells. In contrast to classic cell death, PSGL-1–mediated T-cell death is caspase independent. It involves translocation of apoptosis-inducing factor from mitochondria to nucleus and mitochondrial cytochrome c release. Ultrastructurally, both peripheral condensation of chromatin and apoptotic body were observed in PSGL-1–mediated T-cell death. Collectively, this study demonstrates a novel role for PSGL-1 in controlling activated T-cell death and, thus, advances our understanding of immune regulation.
- National Taiwan University of Arts Taiwan
- Fu Jen Catholic University Taiwan
Cell Nucleus, Membrane Glycoproteins, Cell Death, Flavoproteins, Mesocricetus, Antibodies, Monoclonal, Apoptosis Inducing Factor, Cytochromes c, Membrane Proteins, Mice, Transgenic, CHO Cells, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Microscopy, Electron, Cross-Linking Reagents, Caspases, Cricetinae, Animals, E-Selectin
Cell Nucleus, Membrane Glycoproteins, Cell Death, Flavoproteins, Mesocricetus, Antibodies, Monoclonal, Apoptosis Inducing Factor, Cytochromes c, Membrane Proteins, Mice, Transgenic, CHO Cells, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Microscopy, Electron, Cross-Linking Reagents, Caspases, Cricetinae, Animals, E-Selectin
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