LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7
Copyright policy )LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7
The LIN-2/LIN-7/LIN-10 complex is necessary for Epidermal Growth Factor Receptor (EGFR) basolateral membrane localization and signaling during C. elegans vulval development. Here we found that LIN-10 can independently promote EGFR localization and signaling. Distinct domains of LIN-10 mediate its complex-dependent and complex-independent functions.
- McGill University Health Centre Canada
- McGill University Canada
Cell Membrane, Membrane Proteins, Cell Differentiation, Articles, Genes, erbB-1, Helminth Proteins, Vulva, ErbB Receptors, Protein Transport, Animals, Female, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Carrier Proteins, Signal Transduction
Cell Membrane, Membrane Proteins, Cell Differentiation, Articles, Genes, erbB-1, Helminth Proteins, Vulva, ErbB Receptors, Protein Transport, Animals, Female, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Carrier Proteins, Signal Transduction
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