No Association Between Transmembrane Protein-Tyrosine Phosphatase Receptor Type C (CD45) Exon A Point Mutation (77C>G) and Idiopathic Dilated Cardiomyopathy
Copyright policy )No Association Between Transmembrane Protein-Tyrosine Phosphatase Receptor Type C (CD45) Exon A Point Mutation (77C>G) and Idiopathic Dilated Cardiomyopathy
To investigate whether a 77C>G polymorphism in exon A of the CD45 gene causing a variant CD45RA expression pattern is associated with the development of idiopathic dilated cardiomyopathy (DCM), we studied a total of 414 individuals (104 patients and 310 controls). CD45RA expression pattern on lymphocytes was examined by flow cytometric analysis and subsequently the CD45 77C>G polymorphism was genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). We found 5 patients and 8 control individuals displaying the variant CD45RA expression pattern. All identified individuals carried the heterozygous CD45 77C>G polymorphism. The frequency of the 77G allele in the patient group was 2.4%, which was not significantly different from 1.3% found in the control group (p=0.327). In conclusion, the data of this preliminary study could not reveal any association between the CD45 77C>G polymorphism and susceptibility to idiopathic DCM in a German population.
- Jena University Hospital Germany
Adult, Aged, 80 and over, Cardiomyopathy, Dilated, Male, Exons, Middle Aged, Flow Cytometry, Humans, Leukocyte Common Antigens, Point Mutation, Female, Aged
Adult, Aged, 80 and over, Cardiomyopathy, Dilated, Male, Exons, Middle Aged, Flow Cytometry, Humans, Leukocyte Common Antigens, Point Mutation, Female, Aged
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