No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A
Copyright policy )No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A
According to a recent genome-wide linkage scan and association study of families with m.11778G>A in Thailand, two single nucleotide polymorphisms (SNPs) (rs3749446 and rs1402000) in the presenilins-associated rhomboid-like (PARL) gene were found to be associated with Leber hereditary optic neuropathy (LHON). In order to verify this association in Chinese LHON patients, we genotyped three PARL gene variants (rs3749446, rs953419, and rs1402000) in 179 patients with m.11778G>A and 170 patients with suspected LHON, and compared them to a control population containing the HapMap Chinese and 58 normal individuals analyzed in this study. We identified no association between these PARL gene SNPs and LHON in Chinese patients with m.11778G>A (P>0.05). Haplotype analysis also showed no statistical difference among the three Chinese populations.
- Sun Yat-sen University China (People's Republic of)
- State Key Laboratory of Ophthalmology China (People's Republic of)
- Kunming Institute of Zoology China (People's Republic of)
- Zhongshan Ophthalmic Center, Sun Yat-sen University China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
China, Genotype, Optic Atrophy, Hereditary, Leber, Sequence Analysis, DNA, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Mitochondrial Proteins, Asian People, Gene Frequency, Haplotypes, Metalloproteases, Humans, Point Mutation, Alleles
China, Genotype, Optic Atrophy, Hereditary, Leber, Sequence Analysis, DNA, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Mitochondrial Proteins, Asian People, Gene Frequency, Haplotypes, Metalloproteases, Humans, Point Mutation, Alleles
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