Translational control of GCN4: an in vivo barometer of initiation-factor activity

Name: Translational control of GCN4: an in vivo barometer of initiation-factor activity
Creator: A G, Hinnebusch
Keywords: 0301 basic medicine, 0303 health sciences, Saccharomyces cerevisiae Proteins, Eukaryotic Initiation Factor-2, Saccharomyces cerevisiae, DNA-Binding Proteins, Fungal Proteins, 03 medical and health sciences, Gene Expression Regulation, Fungal, Protein Biosynthesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1994 English Publisher:Elsevier BVJournal:Trends in Biochemical Sciences, volume 19, pages 409-414 (issn: 0968-0004,

Authors: A G, Hinnebusch;

doi: 10.1016/0968-0004(94)90089-2

pmid: 7817398

Translational control of GCN4: an in vivo barometer of initiation-factor activity

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Abstract

Phosphorylation of translation initiation factor-2 (eIF-2) is an adaptive mechanism for downregulating protein synthesis under conditions of starvation and stress. The yeast Saccharomyces has evolved a sophisticated means of increasing translation of GCN4 mRNA when eIF-2 is phosphorylated, allowing the induction of an important stress-response protein when expression of most other genes is decreasing. Because translation of GCN4 mRNA is so tightly coupled to eIF-2 activity, genetic analysis of this system has provided unexpected insights into the regulation of eIF-2 and its guanine nucleotide exchange factor, eIF-2B.

Related Organizations

National Institute of Health
Pakistan

Keywords

Saccharomyces cerevisiae Proteins, Eukaryotic Initiation Factor-2, Saccharomyces cerevisiae, DNA-Binding Proteins, Fungal Proteins, Gene Expression Regulation, Fungal, Protein Biosynthesis, Amino Acids, Phosphorylation, Protein Kinases, Transcription Factors

19 Research products, page 1 of 2

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