STOP gene Phactr4 is a tumor suppressor
Copyright policy )STOP gene Phactr4 is a tumor suppressor
Significance Cell proliferation control is central to tumor suppression. We previously identified hundreds of suppressors of tumorigenesis and/or proliferation (STOP) genes that restrain normal cell proliferation. Here we show that one such STOP gene, phosphatase and actin regulator 4 ( PHACTR4 ), acts to prevent tumorigenesis. Phactr4 suppresses proliferation and transformation in vitro and tumorigenesis in vivo. PHACTR4 is significantly mutated or downregulated in several cancers, and reintroduction of Phactr4 limits proliferation and tumor growth in cells from these cancers. Thus, our studies provide strong evidence that PHACTR4 is a tumor suppressor.
- Brigham and Women's Faulkner Hospital United States
- Howard Hughes Medical Institute United States
- Harvard University United States
- Dana-Farber Cancer Institute United States
570, Mice, Inbred BALB C, Immunoblotting, 610, Mammary Neoplasms, Experimental, Mice, Nude, Breast Neoplasms, Gene Expression Regulation, Neoplastic, Mice, Cell Transformation, Neoplastic, Cell Line, Tumor, Doxycycline, Mutation, MCF-7 Cells, Animals, Humans, Female, RNA Interference, Mammary Glands, Human, Cells, Cultured, Cell Line, Transformed, Cell Proliferation
570, Mice, Inbred BALB C, Immunoblotting, 610, Mammary Neoplasms, Experimental, Mice, Nude, Breast Neoplasms, Gene Expression Regulation, Neoplastic, Mice, Cell Transformation, Neoplastic, Cell Line, Tumor, Doxycycline, Mutation, MCF-7 Cells, Animals, Humans, Female, RNA Interference, Mammary Glands, Human, Cells, Cultured, Cell Line, Transformed, Cell Proliferation
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