A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly
Copyright policy )A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly
Unravelling the SM-SNARE conundrum So-called SNARE proteins mediate and lend specificity to the fusion between different intracellular membranes. The SM proteins are universally required for intracellular vesicle fusion, yet their mechanism of action has long been enigmatic. Baker et al. have solved a piece of the puzzle by “capturing” SNAREs in the process of assembling into fusogenic complexes on the surface of an SM protein. The findings suggest exactly how and why SM proteins help vesicular fusion during intracellular membrane trafficking. Science , this issue p. 1111
- College of New Jersey United States
- Dartmouth College United States
Saccharomyces cerevisiae Proteins, Synaptosomal-Associated Protein 25, Qa-SNARE Proteins, Vesicular Transport Proteins, Membrane Proteins, Saccharomyces cerevisiae, Crystallography, X-Ray, Protein Structure, Secondary, Protein Structure, Tertiary, R-SNARE Proteins, Munc18 Proteins, Protein Binding
Saccharomyces cerevisiae Proteins, Synaptosomal-Associated Protein 25, Qa-SNARE Proteins, Vesicular Transport Proteins, Membrane Proteins, Saccharomyces cerevisiae, Crystallography, X-Ray, Protein Structure, Secondary, Protein Structure, Tertiary, R-SNARE Proteins, Munc18 Proteins, Protein Binding
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