Dependence of Olfactory Bulb Neurogenesis on Prokineticin 2 Signaling
Copyright policy )Dependence of Olfactory Bulb Neurogenesis on Prokineticin 2 Signaling
Neurogenesis persists in the olfactory bulb (OB) of the adult mammalian brain. New interneurons are continually added to the OB from the subventricular zone (SVZ) via the rostral migratory stream (RMS). Here we show that secreted prokineticin 2 (PK2) functions as a chemoattractant for SVZ-derived neuronal progenitors. Within the OB, PK2 may also act as a detachment signal for chain-migrating progenitors arriving from the RMS. PK2 deficiency in mice leads to a marked reduction in OB size, loss of normal OB architecture, and the accumulation of neuronal progenitors in the RMS. These findings define an essential role for G protein–coupled PK2 signaling in postnatal and adult OB neurogenesis.
- University of California, Irvine United States
Neurons, Chemotactic Factors, Chemotaxis, Dopamine, Neuropeptides, Brain, Gene Expression, Apoptosis, Cell Count, Olfactory Bulb, Coculture Techniques, Cell Line, Cerebral Ventricles, Gastrointestinal Hormones, Mice, Inbred C57BL, Mice, Interneurons, Cell Adhesion, Animals, Cell Proliferation
Neurons, Chemotactic Factors, Chemotaxis, Dopamine, Neuropeptides, Brain, Gene Expression, Apoptosis, Cell Count, Olfactory Bulb, Coculture Techniques, Cell Line, Cerebral Ventricles, Gastrointestinal Hormones, Mice, Inbred C57BL, Mice, Interneurons, Cell Adhesion, Animals, Cell Proliferation
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