Structure of a human catalytic step I spliceosome
Copyright policy )Structure of a human catalytic step I spliceosome
Structure of the human spliceosome Catalyzed by the spliceosome, precursor mRNA splicing proceeds in two steps: branching and exon ligation. Transition from the C (catalytic post-branching spliceosome) to the C* (catalytic pre-exon ligation spliceosome) complex is driven by the adenosine triphosphatase/helicase Prp16. Zhan et al. report the cryo-electron microscopy structure of the human C complex, showing that two step I splicing factors stabilize the active site and link it to Prp16. Science , this issue p. 537
- Tsinghua University China (People's Republic of)
- Westlake University China (People's Republic of)
Models, Molecular, Saccharomyces cerevisiae Proteins, RNA Splicing, Cryoelectron Microscopy, DEAD-box RNA Helicases, Catalytic Domain, Biocatalysis, Spliceosomes, Humans, Amino Acid Sequence, RNA Splicing Factors
Models, Molecular, Saccharomyces cerevisiae Proteins, RNA Splicing, Cryoelectron Microscopy, DEAD-box RNA Helicases, Catalytic Domain, Biocatalysis, Spliceosomes, Humans, Amino Acid Sequence, RNA Splicing Factors
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