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Signal Transduction and Targeted Therapy
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Signal Transduction and Targeted Therapy
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Signal Transduction and Targeted Therapy
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Signal Transduction and Targeted Therapy
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Signal-induced PARP1-Erk synergism mediates IEG expression

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 12 Apr 2019 English Publisher:Springer Science and Business Media LLCJournal:Signal Transduction and Targeted Therapy, volume 4 (eissn: 2059-3635, Copyright policy )Funded by:NIH | Possible treatment of coc..., CIHR | unidentified
Authors: John M. Pascal; Malka Cohen-Armon; Adva Yeheskel;

doi: 10.1038/s41392-019-0042-0

pmid: 30993015

pmc: PMC6459926

Abstract

AbstractA recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra- and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. Their binding maintains their long-lasting activity in a synergism, which offers a new pattern for targeted therapy.

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 14
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Top 10%
Average
Top 10%
Green
gold
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