Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD
Copyright policy )Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD
Key Points STAT1−/− BM prevents GVHD induced by delayed donor lymphocyte infusion via the expansion of CD9−Siglec Hhi pDCs, which are low producers of IFNα and IL-12. pDCs recovered from STAT1−/− BM chimeras show increased expression of S100A8, S100A9, and STAT3.
- National Cancer Institute United States
- National Institutes of Health United States
- University of Wisconsin System United States
- University of Wisconsin–Oshkosh United States
- National Institute of Health Pakistan
Male, Mice, Knockout, STAT3 Transcription Factor, Mice, Inbred C3H, Mice, 129 Strain, T-Lymphocytes, Gene Expression, Graft vs Host Disease, Mice, Transgenic, Dendritic Cells, Allografts, Tissue Donors, Mice, Inbred C57BL, Mice, STAT1 Transcription Factor, Animals, Calgranulin B, Calgranulin A, Female, Bone Marrow Transplantation
Male, Mice, Knockout, STAT3 Transcription Factor, Mice, Inbred C3H, Mice, 129 Strain, T-Lymphocytes, Gene Expression, Graft vs Host Disease, Mice, Transgenic, Dendritic Cells, Allografts, Tissue Donors, Mice, Inbred C57BL, Mice, STAT1 Transcription Factor, Animals, Calgranulin B, Calgranulin A, Female, Bone Marrow Transplantation
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