HLA-G expression in malignant melanoma
Copyright policy )HLA-G expression in malignant melanoma
Both, the expression of HLA-G (a non-classical HLA class I molecule) and the loss of classical HLA class I molecules enable tumor cells to evade from immunosurveillance of the host. Whereas HLA-G down-modulates the immune functions of all cells participating in the immune defence mechanisms, defects on HLA class I expression result in the resistance of tumor cells to cytotoxic T lymphocytes attacks. This contribution reviews the HLA-G expression pattern in malignant melanoma lesions, its correlation to the loss of classical HLA class I antigens, and new aspects of HLA-G regulation.
- University of Vienna Austria
- Medical University of Vienna Austria
- Essen University Hospital Germany
- Institut für Immunologie Germany
- Ludwig-Maximilians-Universität München Germany
HLA-G Antigens, Skin Neoplasms, Histocompatibility Antigens Class I, Gene Expression Regulation, Neoplastic, HLA Antigens, Cell Line, Tumor, Humans, Tumor Escape, Immunologic Surveillance, Melanoma
HLA-G Antigens, Skin Neoplasms, Histocompatibility Antigens Class I, Gene Expression Regulation, Neoplastic, HLA Antigens, Cell Line, Tumor, Humans, Tumor Escape, Immunologic Surveillance, Melanoma
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