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Regulation of inflammatory and antiviral signaling by A20

Authors: Kislay Parvatiyar; Edward W. Harhaj;
Regulation of inflammatory and antiviral signaling by A20
Abstract
The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways. Here, we review recent advances illustrating the role of A20 as an essential negative regulator of inflammatory and antiviral signaling.
Related Organizations
- University System of Ohio United States
- Miami University United States
- Sylvester Comprehensive Cancer Center United States
Keywords
Inflammation, Cell Death, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, DNA-Binding Proteins, Virus Diseases, Animals, Humans, Tumor Necrosis Factor alpha-Induced Protein 3, Signal Transduction
Inflammation, Cell Death, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, DNA-Binding Proteins, Virus Diseases, Animals, Humans, Tumor Necrosis Factor alpha-Induced Protein 3, Signal Transduction
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citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).32 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
popularity
Popularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
32
Top 10%
Top 10%
Top 10%
bronze