DrosophilaFACT contributes toHoxgene expression through physical and functional interactions with GAGA factor
Copyright policy )DrosophilaFACT contributes toHoxgene expression through physical and functional interactions with GAGA factor
Chromatin structure plays a critical role in the regulation of transcription.DrosophilaGAGA factor directs chromatin remodeling to its binding sites. We show here thatDrosophilaFACT (facilitateschromatintranscription), a heterodimer of dSPT16 and dSSRP1, is associated with GAGA factor through its dSSRP1 subunit, binds to a nucleosome, and facilitates GAGA factor-directed chromatin remodeling. Moreover, genetic interactions betweenTrithorax-likeencoding GAGA factor andspt16implicate the GAGA factor–FACT complex in expression ofHoxgenesUltrabithorax, Sex combs reduced, andAbdominal-B. Chromatin immunoprecipitation experiments indicated the presence of the GAGA factor–FACT complex in the regulatory regions ofUltrabithoraxandAbdominal-B.These data illustrate a crucial role of FACT in the modulation of chromatin structure for the regulation of gene expression.
Homeodomain Proteins, Molecular Sequence Data, Genes, Homeobox, High Mobility Group Proteins, Gene Expression Regulation, Developmental, Genes, Insect, Regulatory Sequences, Nucleic Acid, Chromatin, Nucleosomes, Animals, Genetically Modified, DNA-Binding Proteins, Mutation, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, Cloning, Molecular, Transcriptional Elongation Factors, Transcription Factors
Homeodomain Proteins, Molecular Sequence Data, Genes, Homeobox, High Mobility Group Proteins, Gene Expression Regulation, Developmental, Genes, Insect, Regulatory Sequences, Nucleic Acid, Chromatin, Nucleosomes, Animals, Genetically Modified, DNA-Binding Proteins, Mutation, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, Cloning, Molecular, Transcriptional Elongation Factors, Transcription Factors
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