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Genetics
Article . 2013 . Peer-reviewed
License: OUP Standard Publication Reuse
Data sources: Crossref
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Genetics
Article
Data sources: UnpayWall
Genetics
Article . 2014
Data sources: Europe PubMed Central
https://dx.doi.org/10.1534/gen...
Article
Data sources: Microsoft Academic Graph
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Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2013 English Publisher:Oxford University Press (OUP)Journal:Genetics, volume 195, pages 289-291 (eissn: 1943-2631, Copyright policy )
Authors: Zhongsheng, Yu; Mengda, Ren; Zhanxiang, Wang; Bo, Zhang; Yikang S, Rong; Renjie, Jiao; Guanjun, Gao;

doi: 10.1534/genetics.113.153825

pmid: 23833182

pmc: PMC3761309

Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila

Abstract

Abstract We report that Cas9/gRNA mediates efficient genetic modifications in Drosophila. Through targeting seven loci, we achieved a germline efficiency of up to 100%. Genes in both heterochromatin and euchromatin can be modified efficiently. Thus the Cas9/gRNA system is an attractive tool for rapid disruption of essentially any gene in Drosophila.

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Keywords

Gene Targeting, Genome, Insect, Animals, Drosophila, CRISPR-Cas Systems

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 323
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.1%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
323
Top 1%
Top 1%
Top 0.1%
hybrid