Powered by OpenAIRE graph
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Developmental Biolog...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Developmental Biology
Article
License: Elsevier Non-Commercial
Data sources: UnpayWall
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Developmental Biology
Article . 1996
License: Elsevier Non-Commercial
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Developmental Biology
Article . 1996 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
versions View all 3 versions

The Role of HOM-C Genes in Segmental Transformations: Reexamination of theDrosophila Sex combs reducedEmbryonic Phenotype

Authors: Julie D. Pederson; Daniel P. Kiehart; James W. Mahaffey;

The Role of HOM-C Genes in Segmental Transformations: Reexamination of theDrosophila Sex combs reducedEmbryonic Phenotype

Abstract

Homeotic genes in the Antennapedia Complex of Drosophila specify identity of the posterior head segments; the labial segment requires Sex combs reduced (Scr) for proper development, Deformed (Dfd) specifies maxillary and mandibular identity, and labial is necessary for intercalary segment identity. Although mutations in these genes cause homeotic transformations during imago development, the only obvious homeotic transformation during embryonic head development is found in Scr mutants, where a partial transformation of the labial segment to a more anterior, maxillary identity has been reported. This transformation is unusual because DFD protein does not accumulate in the labial cells of Scr mutants, although DFD is required for development of maxillary structures. Here, we present evidence that casts doubt on whether the labial to maxillary transformation actually exists in embryos lacking Scr. The observed morphological characteristics and gene expression patterns of various mutant embryos indicate a loss of segmental identity rather than a transformation.

Keywords

Homeodomain Proteins, Embryo, Nonmammalian, Transcription, Genetic, Genes, Homeobox, Gene Expression Regulation, Developmental, Genes, Insect, Cell Biology, Drosophila melanogaster, Phenotype, Mutagenesis, Insect Hormones, Animals, Drosophila Proteins, Molecular Biology, In Situ Hybridization, Developmental Biology, Transcription Factors

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    23
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
23
Average
Top 10%
Average
hybrid