RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells
Copyright policy )RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells
AbstractRetinoic acid (RA) induces embryonic stem cell differentiation. The effects of RA are mediated by retinoic acid receptors (RARs) that promote epigenetic changes controlling gene transcription. We show here that RARγ, in the absence of the ligand RA, is required for deposition of the histone variant H2A.Z and the polycomb group protein Suz12 at RA target genes, and that in embryonic stem cells both RARγ and Suz12 exist in a multi‐protein complex in the absence of ligand. Addition of RA causes removal of H2A.Z and Suz12 from RARγ target genes when the genes are transcriptionally activated. J. Cell. Physiol. 226: 293–298, 2011. © 2010 Wiley‐Liss, Inc.
- Cornell University United States
Mice, Knockout, Receptors, Retinoic Acid, Polycomb Repressive Complex 2, Cell Differentiation, Tretinoin, Retinoic Acid Receptor gamma, Retinoic Acid 4-Hydroxylase, Epigenesis, Genetic, Histones, Repressor Proteins, Mice, Cytochrome P-450 Enzyme System, Gene Expression Regulation, CCAAT-Enhancer-Binding Proteins, Animals, Promoter Regions, Genetic, Cells, Cultured, Embryonic Stem Cells
Mice, Knockout, Receptors, Retinoic Acid, Polycomb Repressive Complex 2, Cell Differentiation, Tretinoin, Retinoic Acid Receptor gamma, Retinoic Acid 4-Hydroxylase, Epigenesis, Genetic, Histones, Repressor Proteins, Mice, Cytochrome P-450 Enzyme System, Gene Expression Regulation, CCAAT-Enhancer-Binding Proteins, Animals, Promoter Regions, Genetic, Cells, Cultured, Embryonic Stem Cells
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