Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations
Copyright policy )Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations
Key Points ASXL2 was mutated in 22.7% (25/110) of adult and pediatric t(8;21)/RUNX1-RUNX1T1 acute myeloid leukemia patients. ASXL2 mutations are mutually exclusive with ASXL1 mutations and occur in t(8;21) but not inv(16)/t(16;16) or RUNX1-mutant AML.
- Paris-Est Sup France
- University of Lille France
- University of Montpellier France
- Institut de Cancérologie de l'Ouest France
- Assistance Publique -Hopitaux De Paris France
Adult, Male, Neoplasm, Residual, Adolescent, Oncogene Proteins, Fusion, Chromosomes, Human, Pair 21, Middle Aged, Translocation, Genetic, Repressor Proteins, Leukemia, Myeloid, Acute, Young Adult, RUNX1 Translocation Partner 1 Protein, Gene Frequency, Child, Preschool, Core Binding Factor Alpha 2 Subunit, Mutation, Humans, Female, Child, Chromosomes, Human, Pair 8
Adult, Male, Neoplasm, Residual, Adolescent, Oncogene Proteins, Fusion, Chromosomes, Human, Pair 21, Middle Aged, Translocation, Genetic, Repressor Proteins, Leukemia, Myeloid, Acute, Young Adult, RUNX1 Translocation Partner 1 Protein, Gene Frequency, Child, Preschool, Core Binding Factor Alpha 2 Subunit, Mutation, Humans, Female, Child, Chromosomes, Human, Pair 8
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