IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis
Copyright policy )IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis
IL-18 deficient (IL-18-/-) mice were used to investigate the role of IL-18 in the pathogenesis of experimental autoimmune neuritis (EAN) which was induced by immunization of the mice with P0 protein peptide 180-199. The clinical course was not different between IL-18-/- and wild-type mice. The splenic mononuclear cell (MNC) proliferation was also similar in both animal groups. However, the percentages of IFN-gamma, IL-10 and IL-12 positive cells were decreased among infiltrating MNC of cauda equine in IL-18-/- mice. This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.
- Karolinska University Hospital Sweden
- University of Rostock Germany
- Jilin University China (People's Republic of)
- Karolinska Institute Sweden
- Jilin University China (People's Republic of)
Male, Mice, Knockout, Time Factors, Interleukin-18, Th1 Cells, Neuritis, Autoimmune, Experimental, Statistics, Nonparametric, Mice, Th2 Cells, Animals, Cytokines, Myelin P0 Protein, Cells, Cultured, Cell Proliferation
Male, Mice, Knockout, Time Factors, Interleukin-18, Th1 Cells, Neuritis, Autoimmune, Experimental, Statistics, Nonparametric, Mice, Th2 Cells, Animals, Cytokines, Myelin P0 Protein, Cells, Cultured, Cell Proliferation
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