Overexpression of AIB1 in Nasopharyngeal Carcinomas Correlates Closely With Advanced Tumor Stage
Copyright policy )Overexpression of AIB1 in Nasopharyngeal Carcinomas Correlates Closely With Advanced Tumor Stage
AIB1, a candidate oncogene in breast cancer, is commonly amplified and overexpressed in several types of human cancers. In this study, expression and amplification of AIB1 in nasopharyngeal carcinoma (NPC) were studied by immunohistochemical analysis and fluorescence in situ hybridization using tissue microarrays, including 80 specimens of NPC and 20 specimens of nonneoplastic nasopharyngeal mucosa. In this NPC cohort, overexpression and amplification of AIB1 was detected in 36 (51%) of 71 and 3 (7%) of 46 NPCs, respectively. Overexpression of AIB1 was observed more frequently in NPCs in late T stages (T3/T4, 24/35 [69%]) than in earlier stages (T1/T2, 12/36 [33%]; P < .05). In addition, 18 (72%) of 25 NPCs with lymph node metastasis (N1-3) showed overexpression of AIB1; the frequency was significantly higher than that in NPCs without node metastasis (N0, 18/49 [39%]; P < .05). These findings suggest that overexpression of AIB1 in NPCs may be important in the acquisition of an invasive and/or metastatic phenotype.
- University of Hong Kong China (People's Republic of)
- Sun Yat-sen University China (People's Republic of)
- Gulf Coast Regional Blood Center United States
- University of Hong Kong (香港大學) China (People's Republic of)
- State Key Laboratory of Oncology in South China China (People's Republic of)
Adult, Male, Adolescent, Amplification, AIB1, Nuclear Receptor Coactivator 3, 616, Humans, In Situ Hybridization, Fluorescence, Aged, Histone Acetyltransferases, Neoplasm Staging, Nasopharyngeal Carcinoma, Carcinoma, Nasopharyngeal Neoplasms, Middle Aged, Immunohistochemistry, Ki-67 Antigen, Tissue Array Analysis, Lymphatic Metastasis, Trans-Activators, Female, Tissue Microarray
Adult, Male, Adolescent, Amplification, AIB1, Nuclear Receptor Coactivator 3, 616, Humans, In Situ Hybridization, Fluorescence, Aged, Histone Acetyltransferases, Neoplasm Staging, Nasopharyngeal Carcinoma, Carcinoma, Nasopharyngeal Neoplasms, Middle Aged, Immunohistochemistry, Ki-67 Antigen, Tissue Array Analysis, Lymphatic Metastasis, Trans-Activators, Female, Tissue Microarray
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