Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse
Copyright policy )Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse
The alpha 3, alpha 5, and beta 4 genes (human gene symbols CHRNA3, CHRNA5, and CHRNB4 respectively; mouse gene symbols Acra-3, Acra-5, and Acrb-4, respectively) are members of the nicotinic acetylcholine receptor gene family and are clustered within a 68-kb segment of the rat genome (Boulter et al., 1990, J. Biol. Chem. 265:4472). By somatic cell hybrid analysis, three cDNAs corresponding to these genes were used to map the homologous loci to human chromosome 15 and to mouse chromosome 9. Linkage analysis using CEPH pedigrees showed that the CHRNA5 gene was closely linked to the following chromosome 15 loci: D15S46, D15S52, D15S28, D15S34, and D15S35. Using interspecies crosses in mice, the Acra-5 gene was found closely linked to the Mpi-1 locus. The mapping of these members of a neurotransmitter receptor gene family may facilitate the identification of relationships between the neurotransmitter receptors and murine or human phenotypes.
- Baylor College of Medicine United States
- National Institute of Health Pakistan
- National Institute of Allergy and Infectious Diseases United States
- Howard Hughes Medical Institute United States
Male, Neurons, Chromosomes, Human, Pair 15, Genetic Linkage, Chromosome Mapping, Hybrid Cells, Receptors, Nicotinic, Pedigree, Rats, Mice, Cricetinae, Multigene Family, Animals, Humans, Female
Male, Neurons, Chromosomes, Human, Pair 15, Genetic Linkage, Chromosome Mapping, Hybrid Cells, Receptors, Nicotinic, Pedigree, Rats, Mice, Cricetinae, Multigene Family, Animals, Humans, Female
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