Aging-related changes in the expression of apoptosis-associated molecules in neurosecretory cells of the mouse hypothalamus
Copyright policy )Aging-related changes in the expression of apoptosis-associated molecules in neurosecretory cells of the mouse hypothalamus
The aim of the present work was to identify the characteristics of the control of apoptosis in neurosecretory centers of aged (18 months) mice on exposure to the immunomodulator interferon-alpha (IA) in comparison with young (two months) mice. Age-related activation of apoptosis in the supraoptic (SON) and paraventricular (PVN) nuclei was found to be mediated by different pathways and could result from changes in the ratio of synthesis of pro-(Bax) and antiapoptotic (Mcl-1, Bcl-2) molecules. In addition, the apoptosis signal cascade in young mice treated with IA was identical in both nuclei, while in aged mice there were differences between the SON and the PVN.
- Institute of Evolutionary Physiology and Biochemistry Russian Federation
- Department of Physiological Sciences Russian Federation
- Pedagogical University Mozambique
- Russian State Vocational Pedagogical University Russian Federation
Male, Aging, Interferon-alpha, Apoptosis, Immunohistochemistry, Neurosecretory Systems, Statistics, Nonparametric, Neoplasm Proteins, Mice, Proto-Oncogene Proteins c-bcl-2, Animals, Myeloid Cell Leukemia Sequence 1 Protein, Apoptosis Regulatory Proteins, Supraoptic Nucleus, Paraventricular Hypothalamic Nucleus, bcl-2-Associated X Protein
Male, Aging, Interferon-alpha, Apoptosis, Immunohistochemistry, Neurosecretory Systems, Statistics, Nonparametric, Neoplasm Proteins, Mice, Proto-Oncogene Proteins c-bcl-2, Animals, Myeloid Cell Leukemia Sequence 1 Protein, Apoptosis Regulatory Proteins, Supraoptic Nucleus, Paraventricular Hypothalamic Nucleus, bcl-2-Associated X Protein
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