Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
Copyright policy )Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.
- University of California, Berkeley United States
- University of California, San Francisco United States
Biochemistry & Molecular Biology, Biomedical and clinical sciences, Saccharomyces cerevisiae Proteins, mitogen-activated protein kinase, MAP Kinase Signaling System, Pheromone, morphogenesis, Saccharomyces cerevisiae, Medical and Health Sciences, Pheromones, Receptors, G-Protein-Coupled, Substance Misuse, G-Protein-Coupled, Gene Expression Regulation, Fungal, Receptors, G protein-coupled receptor, DNA, Fungal, nuclear fusion, polarized morphogenesis, cell fusion, Biomedical and Clinical Sciences, G protein, cell adhesion, Minireviews, Pharmacology and Pharmaceutical Sciences, DNA, Biological Sciences, Heterotrimeric GTP-Binding Proteins, Receptors, Pheromone, protein phosphorylation, cell differentiation, Biological sciences, Fungal, Gene Expression Regulation, post-translational modification, Chemical sciences, cell cycle arrest, scaffold protein, Chemical Sciences, Biochemistry and Cell Biology, Generic health relevance, gene regulation, signal transduction, adaptor protein, Signal Transduction
Biochemistry & Molecular Biology, Biomedical and clinical sciences, Saccharomyces cerevisiae Proteins, mitogen-activated protein kinase, MAP Kinase Signaling System, Pheromone, morphogenesis, Saccharomyces cerevisiae, Medical and Health Sciences, Pheromones, Receptors, G-Protein-Coupled, Substance Misuse, G-Protein-Coupled, Gene Expression Regulation, Fungal, Receptors, G protein-coupled receptor, DNA, Fungal, nuclear fusion, polarized morphogenesis, cell fusion, Biomedical and Clinical Sciences, G protein, cell adhesion, Minireviews, Pharmacology and Pharmaceutical Sciences, DNA, Biological Sciences, Heterotrimeric GTP-Binding Proteins, Receptors, Pheromone, protein phosphorylation, cell differentiation, Biological sciences, Fungal, Gene Expression Regulation, post-translational modification, Chemical sciences, cell cycle arrest, scaffold protein, Chemical Sciences, Biochemistry and Cell Biology, Generic health relevance, gene regulation, signal transduction, adaptor protein, Signal Transduction
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