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Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

Authors: N. Ben-Chetrit; D. Chetrit; R. Russell; C. Korner; M. Mancini; A. Abdul-Hai; T. Itkin; +24 Authors

Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

Abstract

Small-molecule inhibitors of the lipid phosphatase synaptojanin 2 may prevent breast cancer metastasis.

Keywords

Immunoblotting, Gene Dosage, Fluorescent Antibody Technique, Breast Neoplasms, Mice, SCID, Immunohistochemistry, Phosphoric Monoester Hydrolases, ErbB Receptors, Gene Expression Regulation, Neoplastic, Mice, Cell Movement, Cell Line, Tumor, Drug Discovery, Podosomes, Image Processing, Computer-Assisted, Microscopy, Electron, Scanning, Animals, Humans, Female, Neoplasm Metastasis

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    57
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
57
Top 10%
Top 10%
Top 10%